Barret’s özofagusu hastalarında uzun süreli medikal tedavi ve antireflü cerrahisi karşılaştıran A sınıf yayınlardan örnekler
Antireflü cerrahisinin daha başarılı olduğunu söyleyen yayınlar ;
Annals of Surgery • Volume 246, Number 1, July 2007
Probability of progression was 2.9% (1.2–5.5) in surgical patients and 6.8% (2.6 –12.1) in medical patients (P 0.054). Probability of regression was 15.4% (6.1–31.4) in surgical patients and 1.9% (0.4 –7.3) in medical patients (P 0.004).
Ann Surg 2006;243: 58 – 63
LGD was predominant in men (male-to-female ratio: 1.7:1). Mean age was 58 13.5 years. Sixty percent of patients had no endoscopic evidence of esophagitis. A regression from LGD to BE was observed in 12 of 19 (63.2%) patients in the medical group and in 15 of 16 (93.8%) patients in the surgical group (statistically significant difference). Differences between the 2 groups were statistically significant (P 0.03). Conclusion: The results of our study suggest that surgical treatment may be more effective than medical therapy to modify the natural history of LGD in patients with BE, perhaps because it not only controls acid but also biliopancreatic reflux into the esophagus.
