özofagus varis kanamalarýnda somatostatin uygulamasý
özofagus varis kanamalarýnda
250 mcg puþe 1 dakikada ve ardýndan saatte 250 mcg infüzyon 5 gün önerilir. SF veya %5 dextrose içinde verilebilir. bu sürede ýþýktan korunmalýdýr.
To treat upper GI (gastrointestinal) hemorrhage: The
initial dose should be 250 mcg slow IV (over 1 min),
and then immediately followed by a continuous
infusion of 3 mg/12 hr (6 mg/24 hr) for 5 days.
The 3 mg lyophilized powder for continuous infusion should be reconstituted in either sterile normal (0.9%) saline or in 5% dextrose to provide sufficient solution for a 12-hour infusion of somatostatin at a rate of 250 µg/hr (approximately 3.5 µg/kg/hr). Once reconstituted it should be used within 24 hours and should be protected from light during this time.
To treat acute pancreatitis: Same as for GI bleeding except that it may be infused for 44 hours.
To treat enterocutaneous fistulas: Continuous infusions of 6 mg/24 hr (3 mg/12 hr), and the treatment should be maintained until complete closure of the fistula. The dose should then be reduced to 50 % over 48 hour period to avoid any rebound effect.